Cell Polarity and Subcellular RNA Localization (Results and Problems in Cell Differentiation)
Editorial Reviews
Book Description
Selective cytoplasmic organelle and protein targeting has long been thought to constitute the sole determinant of cell polarity and complexity. This view has been changed, however, by the discovery of differential subcellular RNA distribution patterns. Over the past decade it has become clear that selective mRNA sorting and translation contributes to an accumulation of cognate proteins at discrete cellular sites. In this book, various systems are discussed (e.g. Xenopus oocytes, mammalian brain, invertebrate nervous system) in terms of RNA trafficking, RNA-targeting sequences (cis-elements) and RNA-transporting proteins (trans-factors), activity-dependent translational regulation and the significance of the cytoskeleton for neuronal function and plasticity. It also discusses nucleocytoplasmic export of mRNA and viral RNA as another example of subcellular RNA kinesis.
Book Info
Uses reviews of a few selected samples of the RNA kineses field to illustrate the state of the art and point out any problems that remain. Does not include the Drosophila system, as it has been covered extensively elsewhere, instead focusing on the Xenopus oocytes and the mammalian brain.
Cell Polarity and Subcellular RNA Localization (Results and Problems in Cell Differentiation),Dietmar Richter,Springer,3540411429,Carrier proteins,Cell Differentiation,Cytoskeletal proteins,Life Sciences - Biochemistry,Life Sciences - Biology - General,Life Sciences - Cytology,Physiological transport,Polarity (Biology),RNA,Research,Rna (Ribonucleic Acid),Science,Science/Mathematics,DNA translation,RNA Localization,RNA Transport,Science / Biology,cell development
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